The Ghanche District ("Ghanche" means the `great glacier` and is written as "Gangche" by the local people) is the easternmost district of Baltistan. To the east is the Leh District of Ladakh. Northeast is Aksai Chin, (China), to the north and northwest is the Skardu District, to the west is the Astore District, and to the south is the Indian state of Jammu and Kashmir. The Line of Control along the easternmost region of the Ghanche District ends before the start of the Siachen Glacier. (There has been a proposal made to turn the Siachen Glacier region into apeace park.)

The capital of the Ghanche District is Khaplu. The Khaplu and Hushe Valleys form the gateway for the great Baltoro Muztagh, the subrange of the Karakoram that includes the mighty peaks of K2 (8,611 m), Broad Peak (8,047 m), the Gasherbrums (8,000+ meters), and Masherbrum(7,821 m)--all of which are located in the Skardu District.

The highest peak in Ghanche District is Saltoro Kangri (7,742 m), which is the 31st-highest peak in the world and is, in fact, under Indian control since 1984.

Some of the towns in the district are Balghar, Dubla Khan, Doghani, and Lunkha.

Some rivers in the district are the shyok River, the Hushe River, and the Thalle River.

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